Precision in Microfluidics: Revolutionizing Single Cell Analysis
In the field of single cell analysis and PCR (Polymerase Chain Reaction), precise control and manipulation of fluids at a microscale level is crucial.
This case study explores how IMI Life Science designed a microtiter plate with an integrated fluidic circuit (IFC) to accommodate complex flow paths within a compact manifold. By leveraging proportional valve expertise and custom manifold design, the footprint was reduced by 50%, resulting in a more compact, efficient, and reliable solution.
Advanced Microfluidics System within a Compact Space
The task was to design a microtiter plate with an integrated fluidic circuit (IFC) that could accommodate a complex flow path within a compact manifold. The detailed microfluidic flow paths were necessary for accurate and efficient operation of the IFC. The compact manifold design required the integration of multiple valves and channels within a limited space, optimizing the functionality and performance of the system.
The industry encountered challenges in designing such a combination of flow paths within a small volume. The network of microfluidic channels required precise engineering to ensure efficient fluid movement and control. The compact design had to accommodate multiple pathways and components, making it a sophisticated and demanding task.
Using proportional valve expertise and custom manifold design to reduce footprint by 50%
The latest generation of integrated manifolds focused on miniaturization. The original large manifold, measuring 10 by 12 inches, was unsuitable for the smaller next-generation instrument. The new design using Flexisol is now roughly half the size and features compact Flexisol valves with integrated electrical pad mounting, eliminating the need for individual connections to 60 solenoid valves and utilizing PCB connections.
The PMMA manifold enables thermal laser bonding to optimize the fluidic circuit for pneumatic controls. Finite element analysis ensured proper structural support through metal bracing to prevent deformation under load.
This redesign reduced the manifold footprint by 50%, allowing a significant reduction in the instrument's overall size. The improved electrical connections also created cleaner and safer installation, providing a more compact, efficient, and reliable solution that enhances product performance and market competitiveness.